A previous clinical trial has also demonstrated that the consecutive ingestion of Guava Leaf Tea together with every meal improved hypertriglyceridemia and hypercholesterolemia [ 33] (Table ​ (Table3). Especially, CYP2C8, CYP2C9 and CYP3A4, which are typical CYP isoforms, can metabolize many commercial drugs. In contrast, neither side effects resulting from alterations in the parameter values of liver and kidney functions or blood chemistry nor changes in doctor's health interviews were observed during the entire clinical trial period.

Therefore, we studied whether GLT had potential for inhibition or induction of cytochrome P450 (CYP) and an influence on the action of warfarin.Of these 22 patients, 19 received anti-diabetic medication (insulin, sulfonylurea and/or alpha-GI) throughout the trial. There's an herbal quality to guava leaf tea and a slight green tea flavor, even though the beverage doesn't contain any true tea leaves in it. In contrast, at the inactive dose, acarbose and voglibose did not affect the activity of GvEx (250 mg/kg).

A method for producing guava tea leaves, comprising washing, steaming, twisting and then drying guava leaves. poured with hot water, and becomes a guava tea with a slightly light green color in about 5 minutes.

When the guava tea leaves of the present invention described above are poured with hot water for about 5 minutes, they become a light green guava tea and a refreshing guava tea. S-5) Agglomeration The guava leaves, which have been sufficiently twisted, are agglomerated in a state where they are grasped with one hand without being lightly shaped. Taken together, it is suggested that the consecutive ingestion of Guava Leaf Tea with every meal improves diabetes symptoms, such as hyperglycemia, hyperinsulinemia, insulin resistance as well as hyperlipidemia in pre-diabetic and mild diabetic patients with or without hyperlipidemia. In the case of sun drying, the dried state is unlikely to be uniform, and the wrapped state of the outer tea leaves may be disrupted.