Pittler, M. H. and Ernst, E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane.Database.Syst.Rev 2006;(1):CD003230. View abstract. Today, most horse chestnut extracts are made from the seed as opposed to the leaf or bark since the seed contains the highest concentration of escin [ 28]. Dosage

Take extra care if you are taking drugs to dissolve blood clots. These are drugs like alteplase, reteplase, or streptokinase. A 2021 animal study indicates that escin present in a type of horse chestnut originating from Uzbekistan may possess anti-inflammatory and hypoglycemic effects. Once you know it is safe for you, you can select the preparation that is best for you and your health needs. A 2015 review article indicates that horse chestnut seed extract could provide a safe and tolerable treatment option for CVI. Similarly, the European Medicines Agency (EMA) highlights that the extract may relieve symptoms of discomfort and heaviness of the legs associated with CVI. HemorrhoidsSince horse chestnuts reduce fluids in the body, this could increase lithium levels [ 1]. Supplementation Forms Brown K, Scott-Hoy B, Jennings. Efficacy of a Quebracho, Conker Tree, and M. balsamea Willd blended extract in patients with irritable bowel syndrome with constipation. J Gasterenterol Hepatol Res 2015; 4: 1762-1767.

Creams with horse chestnut contain 2% escin and are applied 3-4 times a day up to 2 months [ 15]. User Experiences According to the NICCH, the raw seeds, bark, flowers, and leaves of horse chestnuts are unsafe due to a toxic component. However, it advises that standardized horse chestnut seed extracts from which manufacturers have removed the toxic element appear safe for short-term use. While there is limited evidence, research also suggests that horse chestnut is unlikely to result in liver injury.Additionally, the NICCH and the EMA advise that horse chestnut may have the following undesirable effects:

It's important to follow guidelines on how much horse chestnut to take when taking it internally. Taking too much could cause irritation due to the saponin content. Always read manufacturer guidelines, or refer to a herbalist. How long does it take to work?

In a cell study, P-coumaric acid also helped beneficial gut microbiota detoxify the body [ 20]. Lowering Blood Sugar A magnesium supplement is one option or, alternatively, you can also look to your food to increase your magnesium intake. Try eating more magnesium-rich foods including dark leafy greens, such as spinach and kale, nuts and seeds, fish, avocado, bananas and dark chocolate. When to consult your doctor...