Paracetamol is excreted in breast milk, but not in a clinically significant amount. Available published data do not contraindicate breast feeding.

If you're taking medicines for high blood pressure you shouldn't take Lemsip cold & flu sachets, because the decongestant may make your blood pressure medicine less effective. Other medicine interactions for Lemsip cold & flu related to paracetamol Settipane RA, Stevenson DD. Cross sensitivity with acetaminophen in aspirin-sensitive subjects with asthma. J Allergy Clin Immunol. 1989;84:26-33. Sympathomimetic agents: Concomitant use of phenylephrine with other sympathomimetic amines can increase the risk of hypertension and other cardiovascular side effects (see section 4.3). Liver damage is possible in adults who have taken 10 g or more of paracetamol. Ingestion of 5 g or more of paracetamol may lead to liver damage if the patient has risk factors (see below). Immediate medical advice should be sought in the event of an overdose, even if the patient feels well because of the risk of delayed serious liver damage (see section 4.9).

Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of paracetamol, however, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be discussed with the NPIS or a liver unit. Rare (less than 0.1%): Serious skin reactions such as acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, and toxic epidermal necrolysis Phenylephrine hydrochloride 12.2 mg Indications: For relief of the symptoms of colds and influenza, including the

The antidiabetic medicines exenatide, lixisenatideand liraglutidemay slow down the absorption of paracetamol into the bloodstream, so it might take longer to work if you're using one of these medicines to treat your diabetes. Ask your pharmacist for more advice. Bonkovsky HL, Kane RE, Jones DP, Galinsky RE, Banner B. Acute hepatic and renal toxicity from low doses of acetaminophen in the absence of alcohol abuse or malnutrition - evidence for increased susceptibility to drug toxicity due to cardiopulmonary and renal insufficiency. Hepatology. 1994;19:1141-8.There are many other cold and flu and cough remedies available to buy without a prescription. Many of these will also contain paracetamol, phenylephrine hydrochloride and guaifenesin among their ingredients. Singer AJ, Carracio TR, Mofenson HC. The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. Ann Emerg Med. 1995;26:49-53. Due to the presence of caffeine, the product should be taken with care in patients with a history of peptic ulcers. Adults and adolescents aged 12 years and over should take one sachet every four to six hours as needed, but do not take more than four sachets in 24 hours. There are limited data on the use of guaifenesin in pregnant women. Guaifenesin has been linked with an increased risk of neural tube defects in a small number of women with febrile illness in the first trimester of pregnancy.

LEMSIP MAX ALL IN ONE COLD & FLU CAPSULES, LEMSIP COUGH MAX FOR MUCUS COUGH & COLD: 500mg/100 MG/6.1 MG CAPSULES: Each capsule This product contains lactose. Patients with rare hereditary problems of galactose intolerance, the total lactase deficiency or glucose-galactose malabsorption should not take this medicine Minton NA, Henry JA, Frankel RJ. Fatal paracetamol poisoning in an epileptic. Hum Toxicol. 1988;7:33-4. Do not take more than the recommended dose. Do not take this medicine with any other products that contain paracetamol, as this can easily result in exceeding the maximum dose of paracetamol. Paracetamol is thought to relieve pain by reducing the production of prostaglandins in the brain and spinal cord.Use with caution in patients with hypertension, heart disease, diabetes, hyperthyroidism, hyperexcitability, phaeochromocytoma, prostatic enlargement or close angle glaucoma. Each sachet contains approximately 2.1 g of carbohydrate. Care is advised in the administration of paracetamol to patients with severe renal or severe hepatic impairment. The hazard of overdose is greater in those with non-cirrhotic alcoholic liver disease. Patients should be advised not to take other paracetamol-containing products concurrently. Phenylephrine overdose is likely to result in: nervousness, headache, dizziness, insomnia, increased blood pressure, nausea, vomiting, reflex bradycardia, mydriasis, acute angle closure glaucoma (most likely to occur in those with closed angle glaucoma), tachycardia, palpitations, allergic reactions (e.g. rash, urticaria, allergic dermatitis), dysuria, urinary retention (most likely to occur in those with bladder outlet obstruction, such as prostatic hypertrophy). The maximum daily dose of this product is equivalent to 25.7 % of the WHO recommended maximum daily intake for sodium. fever with or without chills (not present before treatment and not caused by the condition being treated) relief of aches and pains, sore throat, headache, nasal congestion and lowering of temperature Legal Category: GSL.

Hull, HU8 7DS. Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be This product also contains 1973.3mg sucrose per dose (total sugars 2g). Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.Phenylephrine overdose is likely to result in: nervousness, headache, dizziness, insomnia, increased blood pressure, nausea, vomiting, mydriasis, acute angle closure glaucoma (most likely to occur in those with closed angle glaucoma), tachycardia, palpitations, allergic reactions (e.g. rash, urticaria, allergic dermatitis), dysuria, urinary retention (most likely to occur in those with bladder outlet obstruction, such as prostatic hypertrophy). LEMSIP MAX COLD & FLU CAPSULES: Each capsule contains Paracetamol 500 mg, Caffeine 25 mg Phenylephrine hydrochloride 6.1 mg