skyn ICELAND Dissolving Microneedle Eye Patches with Hyaluronic Acid & Peptides: to Hydrate, Firm and Smooth Fine Lines (1 Pack)

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Rodgers,A.M.; Cordeiro,A.S.; Donnelly,R.F. Med.Devices:EvidenceRes. 2019, 12, 379–398. doi:10.2147/mder.s198220 I think Botox and these patches work on different sorts of wrinkles – Botox only works on wrinkles in motion (caused by muscle contractions), whereas these patches work mostly on fine lines where the cause isn’t as deep. Reply

After 6 weeks my eyes are noticeably brighter, and the dark circles are disappearing which is nice to see and the lines around my eyes have softened. I’m going to continue to use weekly to maintain my results and also to see how they continue to improve over time. Vinayakumar,K.B.; Kulkarni,P.G.; Nayak,M.M.; Dinesh,N.S.; Hegde,G.M.; Ramachandra,S.G.; Rajanna,K. J.Micromech.Microeng. 2016, 26, 065013. doi:10.1088/0960-1317/26/6/065013 Sharma,R.; Sircar,P.; Pachori,R.B.; Bhandary,S.V.; Acharya,U.R. J.Mech.Med.Biol. 2019, 19, No.1940011. doi:10.1142/s0219519419400116 Among the ophthalmic preparations, the most commonly used are eye drops [49-51], ointments [52,53], or gels [54,55], containing the drug in a dissolved or suspended form [56,57]. They are applied by medical personnel or by the patient himself to the surface of the eye, to the conjunctival sac, or on the eyelid. Their main disadvantage is the need for frequent dosing, which can be troublesome. Hence, the treatment regimen is rarely followed, leading to a reduction in the effectiveness of the therapy [58,59]. Therefore, apart from designing the vehicle/base composition, drugs are often incorporated into appropriate carriers or introduced into systems whose purpose is to provide the expected concentration in the treated tissue for the desired time period. The most frequently studied and described are liposomes [60,61], micelles [60,62], microparticles [63-65], nanoparticles [66,67], micro- [68,69], and nanoemulsions [70,71]. Unfortunately, it has to be noticed that most technological solutions on the nanoscale are only promising at the laboratory stage. The transfer of such technologies to an industrial scale is often complicated and causes many difficulties [72-74]. Since its first appearance in biomedicine, microtechnology is rapidly entering the world of pharmaceutical sciences, including pharmaceutical technology [1-4]. Due to the impressive evolution of new manufacturing techniques, it offers completely new opportunities to develop very sophisticated and precise drug delivery tools [5,6]. A large number of concepts and implemented projects, which is reflected in a large number of scientific papers, consistently pushes pharmaceutical technology to a new level of coping with various diseases, including those related to the eye [7-10].

Economidou,S.N.; Uddin,M.J.; Marques,M.J.; Douroumis,D.; Sow,W.T.; Li,H.; Reid,A.; Windmill,J.F.C.; Podoleanu,A. Addit.Manuf. 2021, 38, 101815. doi:10.1016/j.addma.2020.101815 Some skincare ingredients with the right properties can penetrate through our skin barrier, but many of them can’t get in. That’s why lots of products are formulated with penetration enhancers to help them get into the skin. One of skin care’s biggest trends right now is microneedling patches, and for good reason. They work. In fact, COVID-19 researchers are currently testing a coronavirus vaccine candidate that would be administered through a microneedle patch. Another well-known method is photolithography. In this technique, a silicon wafer is covered with a photosensitive or photoresistant polymer. The plate is then exposed to UV radiation. A pattern is formed depending on the coverage of the photosensitive or photoresistant layer. The wafer is then etched. A distinction can be made between wet and dry etching. The wet etching process uses a potassium hydroxide solution, while dry etching includes the physical methods ion milling and sputtering and the chemical method high-pressure plasma [156]. Lithographic techniques can be also used to prepare molds for the micromolding method. Micromolding, also known as solvent casting, is quite popular due to cost-effectiveness and simplicity. This method uses a mold usually made of silicone. The prepared mold is filled with a polymer solution or mixture. Then, air voids are removed with a centrifuge or through vacuum and the mold is baked in the oven. After cooling down, the finished microneedles are removed from the matrix [151,156,157]. This type of method is chosen to obtain microneedles for ophthalmic use [158-160].

Indermun,S.; Luttge,R.; Choonara,Y.E.; Kumar,P.; duToit,L.C.; Modi,G.; Pillay,V. J.ControlledRelease 2014, 185, 130–138. doi:10.1016/j.jconrel.2014.04.052 Tucak,A.; Sirbubalo,M.; Hindija,L.; Rahić,O.; Hadžiabdić,J.; Muhamedagić,K.; Čekić,A.; Vranić,E. Micromachines 2020, 11, 961. doi:10.3390/mi11110961Acetyl Hexapeptide-8 This age-fighting peptide has a relaxing effect on the look of fine lines around the eyes that can help delay the onset of deep creases. High performing but gentle on skin our ultimate eye patches are formulated to soften fine lines, strengthen skin elasticity, boost hydration, and brighten the eye area. due to the double compartment structure of the MNs the rapid release of the anti-inflammatory compound (diclofenac) from the fast dissolving HA-based core provided the synergistic effect with the sustained release of DC101 from the outer layer Chiang,B.; Venugopal,N.; Edelhauser,H.F.; Prausnitz,M.R. Exp.EyeRes. 2016, 153, 101–109. doi:10.1016/j.exer.2016.10.011 Albadr,A.A.; Tekko,I.A.; Vora,L.K.; Ali,A.A.; Laverty,G.; Donnelly,R.F.; Thakur,R.R.S. DrugDeliveryTransl.Res. 2022, 12, 931–943. doi:10.1007/s13346-021-01032-2

Subscriptions are the easiest and most cost-effective way to do so, and can be changed in frequency or cancelled at any time. Qiu,Y.; Li,C.; Zhang,S.; Yang,G.; He,M.; Gao,Y. Int.J.Pharm. 2016, 508, 1–9. doi:10.1016/j.ijpharm.2016.05.006 permeation studies on porcine eyeballs showed that due to application of the MN patches the total amount of released dye was close to 18%, whereas from flat patches only 1% was determined after 24 h Yu,W.; Jiang,G.; Liu,D.; Li,L.; Chen,H.; Liu,Y.; Huang,Q.; Tong,Z.; Yao,J.; Kong,X. Mater.Sci.Eng.,C 2017, 71, 725–734. doi:10.1016/j.msec.2016.10.063Khosraviboroujeni,A.; Mirdamadian,S.Z.; Minaiyan,M.; Taheri,A. DrugDeliveryTransl.Res. 2022, 12, 1195–1208. doi:10.1007/s13346-021-01006-4 Souto,E.B.; Dias-Ferreira,J.; López-Machado,A.; Ettcheto,M.; Cano,A.; CaminsEspuny,A.; Espina,M.; Garcia,M.L.; Sánchez-López,E. Pharmaceutics 2019, 11, 460. doi:10.3390/pharmaceutics11090460